Impact of Crystal Habit on the Dissolution Rate and In Vivo Pharmacokinetics of Sorafenib Tosylate

The dissolution rate is the rate-limiting step for Biopharmaceutics Classification System (BCS) class II drugs to enhance their in vivo pharmacokinetic behaviors. There are some factors affecting rate, such as polymorphism, particle size, and crystal habit. In this study, improve pharmacokinetics of sorafenib tosylate (Sor-Tos), a BCS drug, two habits Sor-Tos were prepared. A plate-shaped habit (ST-A) needle-shaped (ST-B) harvested by recrystallization from acetone (ACN) n-butanol (BuOH), respectively. surface chemistry was determined powder X-ray diffraction (PXRD) data, molecular modeling, face indexation analysis, confirmed photoelectron spectroscopy (XPS) data. results showed that ST-B had larger hydrophilic than ST-A, subsequently higher substantial enhancement performance ST-B.